Baba Ghulam Shah Badshah University, Rajouri, (J&K)

Research

Dr. Shoeb Ahmad

Research Projects Undertaken:

1. Engineering Bacillus subtilis lipase for thermostability and proteolytic resistance. (Duration: 3 Years; Jan 2009-Jan2012) CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India.

2. The mechanism for microtubule depolymerization by kinesins. (Duration: 2 Years; July 2013-June 2015) Centre National de la Recherche Scientifique, Gif sur Yvette, France.

3. Affinity Maturation of Tubulin binding DARPins by ribosome display (Duration: 2 months; April-June-2012) Department of Biochemistry, University of Zurich, Switzerland

Selected Publications:

1. Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin. Wang W., Cantos-Fernandes S., Lv Y., Kuerban H., Ahmad S., Wang C and Gigant B. Nature Communications 2017 Jul 10;8(1): 70, doi: 10.1038/s41467-017-00091-9 ISSN: 2041-1723 (Online) [Impact Factor: 12.124; Citations: 10

2. Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin. Ahmad S., Pecqueur L., Dreier B., Hamdane D., Nicaise M. A., Plückthun A., Knossow M. and Gigant B. Nature-Scientific Reports 2016 Jul 6; 6:28922. doi: 10.1038/srep28922 ISSN: 2045-2322 [Impact Factor: 5.578; Citations: 12]

3. Engineering deamidation-susceptible asparagines leads to improved stability to thermal cycling in a lipase. Bhanuramanand K. Ahmad S. and Rao N. M. Protein Science Oct 2014; 23(10): 1479-90. ISSN: 1469-896X/0961-8368 [Impact Factor₂₀₁₄: 2.861; Citation: 4]

4. Probing protein stability and proteolytic resistance of Bacillus subtilis lipase by loop scanning: A comprehensive mutational analysis. Ahmad S., Kumar V., Ramanand B. K. and Rao N. M. Protein Science March 2012; 21(3): 433-46. ISSN: 1469-896X/0961-8368 [Impact Factor₂₀₁₁: 2.798; Citations: 41]

5. In vitro evolved non-aggregating and thermostable lipase: Structural and thermodynamic investigation. Kamal M. Z.*, Ahmad S.*, Molugu T.R., Vijayalakshmi A., Deshmukh M.V., Sankarnarayanan R. and Rao N.M. J Mol Biol. Oct. 28 2011; 413 (3): 726-41. (* Eq. Contr.) ISSN:0022-2836 [Impact Factor₂₀₁₁: 4.001; Citations: 54]

Dr. Arif Taslim Jaan

Research Projects Undertaken:

1. Studying role of muscle satellite cells (MSCs) in muscle development and amelioration of muscle dystrophies by natural compounds. Duration: 3.5 years (2014-2017), Yeungnam University, Republic of Korea.

2. Biochemical and functional characterization of ABC transporters and study their role in the pathogenesis of Streptococcus pneumonia. Duration: 2 years (2012-2014) National Institute of Immunology, New Delhi, India.

Selected Publications:

1. Jan AT, Rahman S, Khan S, Abdullah TS, Choi I. (2019) Biology,Pathophysiological role and clinical implications of exosomes: A critical appraisal. Cells. 8; 99 (IF 4.8)

2. Rahman S, Archana A, Jan AT, Dutta D, Shanker A, Kim J, Minakshi R. (2019) Molecular insights into the relationshipbetween autoimmune thyroid diseases and breast cancer: A critical perspective on autoimmunity and ER stress. Front Immunol. (Accepted) (IF 5.511)

3. Rahman S, Archana A, Dutta D, Kumar V, Kim J, Jan AT, Minakshi R. (2019) The onus of cannabinoids in interrupting molecular odyssey of breast cancer: A critical perspective on UPRER and beyond. Saudi Pharm J. (Accepted) (IF 3.110)

4. Khan S, Imran A, Malik A, Chaudhary AA, Rub A, Jan AT. Syed ZB, Rolfo C. (2018) Bacterial imbalance and gut pathologies: Association and contribution of E. coli in inflammatory bowel diseases. Crit Rev Clin Lab Sci. (Accepted) (IF 6.481)

5. Sultan I, Rahman S, Jan AT^*, Siddiqui MT, Mondal AH, Haq QMR^* (2018) Antibiotics, resistome and resistance mechanisms: A bacterial perspective. Front Microbiol. (Accepted) (IF 4.165)

6. Lone JB, Koh WN, Parray HA, Paek WK, Lim JH, Rather I, Jan AT^*. (2018) Gut microbiome: Microflora association with obesity and obesity related commorbidities. Microb Pathogen. (Accepted) (IF 2.332)

7. Rahman S, Archana A, Azam M, Jan AT, Dutta D, Minakshi R. (2018) Role of osmolytes and their transporter system in pathogen survival and pathogenecity. Current Drug Metabolism. (Accepted) (IF 2.655)

Dr. Tanvir-ul-Hasan Dar

Selected Publications:

1. Maji S, Dahiya P, Waseem M , Dwivedi N, Bhat DS, Dar TH, Thakur JK. (2019). Interaction map of Arabidopsis Mediator complex expounding its topology. Nucleic Acids Research 1–17.

2. Rather ZA, Wachkoo AA, Khuroo AA, Dar AR, Dar TH (2019). First record of Aspicera hartigi (Hymenoptera, Figitidae) from India, withobservations on its foraging behavior on Ephedra plants. Journal of Asia-Pacific Biodiversity, DOI 10.1016. 2019.03.007.

3. Dar TH, Shakeel R, Verma S (2018). Comparative Germplasm Characterization of Maize (Zea mays L.) in Rajouri Region of Pir Panjal Himalaya J & K (India), based on Morphological and ISSR Markers. Journal of Crop Science and Biotechnology, 21: 43-55.

4. Rasheed S, Khuroo AA, Ganie AH, Mehraj G, Dar TH, Dar GH (2018). Correct taxonomic delimitation of Nasturtium microphyllum Rchb. From Nasturtium officinale R. Br. (Brassicaceae) in Kashmir Himalaya, India. Journal of Asia-Pacific Biodiversity, 11: 154-157.

5. Dar TA, Uddin M, Ali A, Khan MMA, Dar TH (2017). Understanding the Dynamics of Phosphorus Starvation and Plant Growth. In: M. Naeem et al. (eds.), Essential Plant Nutrients, pp. 147-154. Springer international publishing AG. DOI 10.1007/978-3-319- 58841-4-7.

Dr. Raja Amir Hasan

Selected Publications:

1. Yaser Rafiq Mir, Raja A.H Kuchay (2019). Advances in identification of genes involved in autosomal recessive intellectual disability: a brief review. J Med Genet. doi: 10.1136/jmedgenet-2018-105821.

2. Raja AH Kuchay, Yaser Rafiq Mir, Xue Zeng, Asima Hassan, Javed Musarrat, Iqbal Parwez, Christoph Kernstock, Andreas Traschütz, Matthis Synofzik (2019). ARSACS as a Worldwide Disease: Novel SACS Mutations Identified in a Consanguineous Family from the Remote Tribal Jammu and Kashmir Region in India. Cerebellum. doi: 10.1007/s12311-019- 01028-2.

3. Raja A.H Kuchay (2016). A review of complementary therapies for chemotherapy induced gastrointestinal mucositis. Drug Discoveries & Therapeutics. 10(6):292-299 (ISSN: 1881-7831; Indexed; International; UGC Approved)

4. Raja A.H Kuchay, B.R.Thapa, A. Mahmood, S. Mahmood (2015). Screening for lactase persistence associated genotypes in cattle domestication groups of northern India. Mediterranean Journal of Nutrition and Metabolism 8:61–66 (ISSN: 1973-798X; Indexed; International; UGC Approved)

5. Raja A.H Kuchay, B.R.Thapa, A. Mahmood, M. Anwar, S. Mahmood (2015). Lactase genetic polymorphisms and celiac disease in children: a cohort study. Annals of Human Biology 42(1): 101–104 (ISSN: 0301-4460; Indexed; International; UGC Approved)

Dr. Salim Reshi

Selected Publications:

1. Mohd Salim Reshi, Chhavi Uthra, Deepa Yadav, Samta Sharma, Asha Singh, Anjali Sharma, Amita Jaswal, Neelu Sinha, Sadhana Shrivastava, Sangeeta Shukla. Silver Nanoparticles Protect Acetaminophen Induced Acute Hepatotoxicity: A Biochemical and Histopathological Approach. Regulatory Toxicology and Pharmacology. 2017; 90: 36-41 (IF= 2.221)

2. Mohd Salim Reshi, Sadhana Shrivastava, Amita Jaswal, Neelu Sinha, Chhavi Uthra, Sangeeta Shukla. Gold nanoparticles ameliorate Acetaminophen Induced Hepato-Renal Injury in Rats. Experimental and Toxicologic Pathology 2017; 69: 231–240 (IF= 1.975)

3. Chhavi Uthra, Sadhana Shrivastava, Amita Jaswal, Neelu Sinha, Mohd. Salim Reshi and Sangeeta Shukla.Therapeutic potential of quercetin against acrylamide induced toxicity in rats. Biomedicine & Pharmacotherapy. 2017; 86: 705–714 (IF= 2.759)

4. Amita Jaswal, Monika Sharma, Suchita Raghuvanshi, Samta Sharma, Mohd Salim Reshi, Chhavi Uthra, & Sangeeta Shukla. Therapeutic Efficacy of Nigella sativa Linn. Against Antituberculosis Drug–Induced Hepatic Injury in Wistar Rats. Journal of Environmental Pathology, Toxicology and Oncology. 2016; 35(1):13–25 (IF= 1.246)

Microbiology Programme